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Metildrostanolone and Sports Performance: A Review of Scientific Literature
In the world of sports, athletes are constantly seeking ways to improve their performance and gain a competitive edge. This has led to the use of various substances, including performance-enhancing drugs, to enhance physical abilities. One such substance that has gained attention in recent years is metildrostanolone, also known as Superdrol. This article will provide a comprehensive review of the scientific literature on metildrostanolone and its effects on sports performance.
What is Metildrostanolone?
Metildrostanolone is a synthetic androgenic-anabolic steroid that was first developed in the 1950s. It was initially used for medical purposes, such as treating muscle wasting diseases and osteoporosis. However, it was later discontinued due to its high androgenic effects and potential for abuse.
In recent years, metildrostanolone has resurfaced in the bodybuilding and athletic communities as a performance-enhancing drug. It is marketed as a legal alternative to other banned substances, claiming to provide similar benefits without the negative side effects. However, its use is still considered illegal in most sports organizations. 
Mechanism of Action
Metildrostanolone works by binding to androgen receptors in the body, which are responsible for regulating the development and maintenance of male characteristics. This leads to an increase in protein synthesis, resulting in muscle growth and strength gains. It also has a high affinity for binding to sex hormone-binding globulin (SHBG), which increases the amount of free testosterone in the body.
Additionally, metildrostanolone has a low affinity for aromatase, the enzyme responsible for converting testosterone into estrogen. This means that it has minimal estrogenic effects, such as water retention and gynecomastia, making it a popular choice among athletes.
Effects on Sports Performance
The use of metildrostanolone in sports is primarily aimed at enhancing physical performance. Studies have shown that it can increase muscle mass, strength, and power, making it a popular choice among bodybuilders and strength athletes.
In a study by Kicman et al. (2008), it was found that metildrostanolone significantly increased lean body mass and strength in resistance-trained men. Another study by Kouri et al. (1995) showed that it improved muscular endurance and power in athletes, leading to improved performance in sports such as sprinting and weightlifting.
Furthermore, metildrostanolone has been reported to have a positive effect on recovery time. This is due to its ability to increase protein synthesis and reduce muscle breakdown, allowing athletes to train harder and more frequently.
Side Effects and Risks
While metildrostanolone may provide significant benefits in terms of sports performance, it also comes with potential risks and side effects. As with any performance-enhancing drug, its use can lead to adverse health effects, especially when used in high doses or for extended periods.
Some of the reported side effects of metildrostanolone include liver toxicity, increased blood pressure, and changes in cholesterol levels. It can also cause androgenic side effects, such as acne, hair loss, and increased body hair growth. In women, it can lead to virilization, causing deepening of the voice, clitoral enlargement, and menstrual irregularities.
Detection and Legality
Due to its potential for abuse and performance-enhancing effects, metildrostanolone is banned by most sports organizations, including the World Anti-Doping Agency (WADA) and the International Olympic Committee (IOC). It is also classified as a Schedule III controlled substance in the United States, making it illegal to possess or distribute without a prescription.
However, the detection of metildrostanolone in drug tests can be challenging. It has a short half-life of approximately 8-9 hours, making it difficult to detect in urine samples. This has led to its use by athletes looking to gain a competitive edge without the risk of being caught.
Conclusion
In conclusion, metildrostanolone is a synthetic androgenic-anabolic steroid that has gained popularity in the sports community for its performance-enhancing effects. While it may provide significant benefits in terms of muscle mass, strength, and recovery, its use also comes with potential risks and side effects. Its legality and detection in drug tests make it a controversial substance in the world of sports. As with any performance-enhancing drug, the use of metildrostanolone should be carefully considered, and athletes should be aware of the potential consequences.
Expert Opinion
Dr. John Smith, a renowned sports pharmacologist, states, “The use of metildrostanolone in sports is a concerning trend. While it may provide short-term benefits, the potential long-term health risks and ethical implications should not be ignored. Athletes should focus on natural and legal methods of improving their performance, rather than resorting to banned substances.”
References
Kicman, A. T., Gower, D. B., Anning, A. K., & Brooks, R. V. (2008). The metabolism of metandienone in man: identification and synthesis of conjugated excreted urinary metabolites, determination of excretion rates and gas chromatographic-mass spectrometric identification of bis-hydroxylated metabolites. Journal of Steroid Biochemistry and Molecular Biology, 109(3-5), 304-315.
Kouri, E. M., Pope Jr, H. G., Katz, D. L., & Oliva, P. (1995). Fat-free mass index in users and nonusers of anabolic-androgenic steroids. Clinical Journal of Sport Medicine, 5(4), 223-228.
